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PD168393

CAT: 0804-HY-13896-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13896-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PD168393 is a potent, selective and cell-permeable inhibitor of EGFR tyrosine kinase and ErbB2. PD168393 irreversiblely inactivates EGF receptor (IC50=0.7 nM) and is inactive against insulin receptor, PDGFR, FGFR and PKC[1].
CAS Number
194423-15-9
UNSPSC
12352005
Hazard Statement
H302
Target
Apoptosis; Autophagy; EGFR
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/PD168393.html
Purity
98.58
Solubility
DMSO : ≥ 30 mg/mL
Smiles
C=CC(NC1=CC2=C(NC3=CC=CC(Br)=C3)N=CN=C2C=C1)=O
Molecular Formula
C17H13BrN4O
Molecular Weight
369.22
Precautions
H302
References & Citations
[1]D W Fry, et al. Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor. Proc Natl Acad Sci U S A. 1998 Sep 29;95 (20) :12022-7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1

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