Dopamine

• Description :

  Dopamine is a catecholamine neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain. Dopamine plays several important roles in the brain and body[1]. Dopamine acts through D2 dopamine receptors to induce endocytosis of VEGFR2, which is critical for promoting angiogenesis[1].

• Product Name Alternative :

  ASL279 (free base)

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Dopamine Receptor; Endogenous Metabolite; Ferroptosis

• Type :

  Natural Products

• Related Pathways :

  Apoptosis; GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/dopamine.html

• Purity :

  98.56

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  OC1=CC=C(CCN)C=C1O

• Molecular Formula :

  C8H11NO2

• Molecular Weight :

  153.18

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Juárez Olguín H, et al. The Role of Dopamine and Its Dysfunction as a Consequence of Oxidative Stress. Oxid Med Cell Longev. 2016;2016:9730467.|[2]Basu S, et al. The neurotransmitter dopamine inhibits angiogenesis induced by vascular permeability factor/vascular endothelial growth factor. Nat Med. 2001 May;7 (5) :569-74.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, protect from light, stored under nitrogen)

• Scientific Category :

  Natural Products

• Clinical Information :

  Launched

• Isoform :

  Microbial Metabolite

• Citation 01 :

  ACS Appl Mater Interfaces. 2025 Nov 26;17 (47) :64149-64167.|bioRxiv. 2023 Oct 13.|bioRxiv. 2025 Oct 22.|J Solid State Electrochem. 2025 Jan 17.|Nat Commun. 2025 Jan 2;16 (1) :323.|Biomed Pharmacother. 2019 Nov:119:109419.|bioRxiv. 2025 Oct 12.|Eur J Pharmacol. 2023 Dec 15:961:176174.|Eur J Pharmacol. 2025 Jul 5:998:177498.|Immunity. 2025 Aug 12:S1074-7613 (25) 00314-0.|Int J Mol Sci. 2022 Oct 17;23 (20) :12420.|Int J Nanomedicine. 2024 Jul 3:19:6717-6730.|Nat Commun. 2024 Feb 6;15 (1) :1122.|New J Chem. 03 Aug 2022.|Phytother Res. 2023 Aug;37 (8) :3296-3308.|Sci Adv. 2023 Jun 2;9 (22) :eadg3365.

• CAS Number :

  [51-61-6]