Anisodamine

• Description :

  Anisodamine (6-Hydroxyhyoscyamine), a belladonna alkaloid, is a non-subtype-selective muscarinic, and also a nicotinic cholinoceptor antagonist. Anisodamine employs in traditional Chinese medicine for many ailments, mainly to improve the microcirculation in states of shock, and also in organophosphate poisoning[1][2].

• Product Name Alternative :

  6-Hydroxyhyoscyamine

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H319

• Target :

  MAChR

• Type :

  Natural Products

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease; Cancer

• Assay Protocol :

  https://www.medchemexpress.com/Anisodamine.html

• Concentration :

  10mM

• Purity :

  99.02

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  CN1[C@H]2[C@@H](O)C[C@@H]1C[C@H](OC([C@@H](C3=CC=CC=C3)CO)=O)C2

• Molecular Formula :

  C17H23NO4

• Molecular Weight :

  305.37

• Precautions :

  H302, H319

• References & Citations :

  [1]Eisenkraft A, et al. Possible role for anisodamine in organophosphate poisoning. Br J Pharmacol. 2016 Jun;173 (11) :1719-27.|[2]Liu C, et al. Antishock effect of anisodamine involves a novel pathway for activating alpha7 nicotinic acetylcholine receptor. Crit Care Med. 2009;37 (2) :634-641.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  Launched

• CAS Number :

  [55869-99-3]