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Tocofersolan

CAT: 0804-HY-B0717-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0717-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tocofersolan is synthetic polyethylene glycol derivative of α-tocopherol. Tocofersolan is an orally active and water-soluble analog of vitamin E. Tocofersolan can reduce neurobehavioral deficits in zebrafish embryos exposed to moderate and high concentrations of BaP during early development. Tocofersolan shows antioxidant activity. Tocofersolan can be used to provide an orally bioavailable source of vitamin E[1][2][3].
CAS Number
9002-96-4
Product Name Alternative
TPGS; D-α-Tocopherol polyethylene glycol 1000 succinate; Vitamin E-TPGS
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Drug Derivative
Type
Reference compound
Related Pathways
Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Tocofersolan.html
Purity
98.0
Solubility
DMSO : 100 mg/mL (ultrasonic) |Ethanol : 50 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
Smiles
CC1=C(CCC(CCCC(C)CCCC(C)CCCC(C)C)(C)O2)C2=C(C)C(C)=C1OC(CCC(OCCO)=O)=O.[n]
Molecular Weight
1513.00
Precautions
H302, H315, H319, H335
References & Citations
[1]Rehim WM, et al. Antioxidant capacity in Fasciola hepatica patients before and after treatment with triclabendazole alone or in combination with ascorbic acid (vitamin C) and tocofersolan (vitamin E) . Arzneimittelforschung. 2003;53 (3) :214-20.|[2]Tan S, et al. Recent developments in d-α-tocopheryl polyethylene glycol-succinate-based nanomedicine for cancer therapy [published correction appears in Drug Deliv. 2017 Nov;24 (1) :1930]. Drug Deliv. 2017;24 (1) :1831-1842. |[3]Holloway Z, et al. The use of tocofersolan as a rescue agent in larval zebrafish exposed to benzo[a]pyrene in early development. Neurotoxicology. 2021 Sep;86:78-84.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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CatalogName
TRC-T526075-25GTocofersolan

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