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Aminophylline

CAT: 0804-HY-B0140-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0140-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Aminophylline is a competitive and non-selective phosphodiesterase (PDE) inhibitor. Aminophylline is a competitive adenosine receptor antagonist. Aminophylline has apulmonary vasodilator action as well as a bronchodilator action and has the potential for asthma research[1][2].
CAS Number
317-34-0
UNSPSC
12352005
Hazard Statement
H301
Target
Adenosine Receptor; Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/Aminophylline.html
Purity
99.68
Solubility
DMSO : 14.29 mg/mL (ultrasonic) |H2O : 6.25 mg/mL (ultrasonic)
Smiles
O=C(N1C)N(C)C2=C(N=CN2)C1=O.O=C(N3C)N(C)C4=C(N=CN4)C3=O.NCCN
Molecular Formula
C16H24N10O4
Molecular Weight
420.43
Precautions
H301
References & Citations
[1]Daly JW, et al. Adenosine receptors: development of selective agonists and antagonists. Prog Clin Biol Res. 1987;230:41-63.|[2]Ming-Chih Yu, et al. Luteolin, a non-selective competitive inhibitor of phosphodiesterases 1-5, displaced [3H]-rolipram from high-affinity rolipram binding sites and reversed xylazine/ketamine-induced anesthesia. ur J Pharmacol. 2010 Feb 10;627 (1-3) :269-75.|[3]E Tai, et al. Response of blood gas tensions to aminophylline and isoprenaline in patients with asthma. Thorax. 1967 Nov;22 (6) :543-9.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
Launched
Citation 01
3 Biotech. 2025 Apr;15 (4) :72.|Biol Proced Online. 2025 Jun 16;27 (1) :21.|Cell Chem Biol. 2025 Sep 18;32 (9) :1140-1149.e3.|Cell Rep Med. 2023 Jun 20;4 (6) :101061.|Cell Rep Methods. 2023 Oct 23;3 (10) :100599.|Eur J Drug Metab Pharmacokinet. 2022 Sep;47 (5) :639-652.|Exp Brain Res. 2024 Aug;242 (8) :1983-1998.|Int J Mol Sci. 2023 Jan 5;24 (2) :1019.|Int J Mol Sci. 2024 Mar 3;25 (5) :2947.|Int J Mol Sci. 2025 Nov 10;26 (22) :10883.|Pharmacol Res Perspect. 2020 Apr;8 (2) :e00575.|Research Square Preprint. 2020 Oct.

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