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SYM2206

CAT: 0804-HY-18689-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-18689-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SYM2206 is a potent and non-competitive AMPA receptor antagonist, with an IC50 of 1.6 μM. SYM2206 blocks Nav1.6-mediated persistent currents[1][2].
CAS Number
173952-44-8
UNSPSC
12352005
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/SYM2206.html
Concentration
10mM
Purity
99.83
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N1N=C(C2=CC=C(N)C=C2)C3=C(C=C4C(OCO4)=C3)C1C)NCCC
Molecular Formula
C20H22N4O3
Molecular Weight
366.41
References & Citations
[1]Welch NC, et al. Traditional AMPA receptor antagonists partially block Na v1.6-mediated persistent current. Neuropharmacology. 2008 Dec;55 (7) :1165-71.|[2]Bleakman D, et, al. Kainate receptor agonists, antagonists and allosteric modulators. Curr Pharm Des. 2002;8 (10) :873-85.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AMPA Receptor

Alternative Products

CatalogName
561343SYM2206
A20843-25SYM2206 25mg
A20843-1SYM2206 1mg
A20843-50SYM2206 50mg
A20843-5SYM2206 5mg
A20843-100SYM2206 100mg
A20843-10SYM2206 10mg
A20843-10mM-DSYM2206 10mM * 1mL in DMSO

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