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Recombinant Sindbis virus Non-structural polyprotein, partial

CAT: 0399-CSB-EP361019SHZ-01Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0399-CSB-EP361019SHZ-01Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Product Name Alternative
(Non-structural polyprotein) (p270 nonstructural polyprotein) (Non-structural protein 4) (nsP4)
Abbreviation
Recombinant Sindbis virus Non-structural polyprotein, partial
UniProt
P03317
Expression Region
1348-1896aa
Organism
Sindbis virus (SINV)
Target Sequence
APSYRTKRENIADCQEEAVVNAANPLGRPGEGVCRAIYKRWPTSFTDSATETGTARMTVCLGKKVIHAVGPDFRKHPEAEALKLLQNAYHAVADLVNEHNIKSVAIPLLSTGIYAAGKDRLEVSLNCLTTALDRTDADVTIYCLDKKWKERIDAALQLKESVTELKDEDMEIDDELVWIHPDSCLKGRKGFSTTKGKLYSYFEGTKFHQAAKDMAEIKVLFPNDQESNEQLCAYILGETMEAIREKCPVDHNPSSSPPKTLPCLCMYAMTPERVHRLRSNNVKEVTVCSSTPLPKHKIKNVQKVQCTKVVLFNPHTPAFVPARKYIEVPEQPTAPPAQAEEAPEVVATPSPSTADNTSLDVTDISLDMDDSSEGSLFSSFSGSDNSITSMDSWSSGPSSLEIVDRRQVVVADVHAVQEPAPIPPPRLKKMARLAAARKEPTPPASNSSESLHLSFGGVSMSLGSIFDGETARQAAVQPLATGPTDVPMSFGSFSDGEIDELSRRVTESEPVLFGSFEPGEVNSIISSRSAVSFPLRKQRRRRRSRRTEY
Tag
Tag-Free
Type
Developed Protein
Source
E.coli
Field of Research
Others
Relevance
Inactive precursor of the viral replicase, which is activated by cleavages carried out by the viral protease nsP2.
Endotoxin
Not test
Purity
Greater than 85% as determined by SDS-PAGE.
Activity
Not Test
Form
Liquid or Lyophilized powder
Buffer
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Molecular Weight
60.4 kDa
References & Citations
"Different types of nsP3-containing protein complexes in Sindbis virus-infected cells." Gorchakov R., Garmashova N., Frolova E., Frolov I. J. Virol. 82:10088-10101 (2008)
Storage Conditions
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Protein Length
Partial

UniProtKB · P03317

Polyprotein P1234

POLN_SINDV · Sindbis virus

View on UniProt ↗
Primary accession
P03317
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
—
Protein existence
1: Evidence at protein level
Organism
Sindbis virus (SINV)
Taxonomy ID
11034
Alternative names
P1234
EC number
—
Processing
—
Secondary accessions
Q87644
Protein keywords

Technical term

3D-structureReference proteome

Ligand

ATP-bindingGTP-bindingMetal-bindingNucleotide-bindingS-adenosyl-L-methionineZinc

Biological process

Eukaryotic host gene expression shutoff by virusEukaryotic host transcription shutoff by virusHost gene expression shutoff by virusHost-virus interactionInhibition of host innate immune response by virusInhibition of host interferon signaling pathway by virusInhibition of host RNA polymerase II by virusInhibition of host STAT1 by virusInterferon antiviral system evasionmRNA cappingmRNA processingViral immunoevasionViral RNA replication

Molecular function

HelicaseHydrolaseMethyltransferaseMultifunctional enzymeNucleotidyltransferaseProteaseRNA-bindingRNA-directed RNA polymeraseThiol proteaseTransferase

Cellular component

Host cell membraneHost cell projectionHost cytoplasmHost cytoplasmic vesicleHost membraneHost nucleusMembrane

PTM

LipoproteinPalmitatePhosphoproteinUbl conjugation

Coding sequence diversity

RNA suppression of termination

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