Products for Research Use Only
RegisterLogin

LSN 3213128

CAT: 0804-HY-107981-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-107981-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
LSN 3213128 is a selective, nonclassical, orally bioavailable antifolate with potent and specific inhibitory activity for aminoimidazole-4-carboxamide ribonucleotide formyltransferase (AICARFT) with IC50 of 16 nM. LSN 3213128 exhibits anti-tumor activity[1].
CAS Number
1941211-99-9
UNSPSC
12352005
Target
Antifolate
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lsn-3213128.html
Concentration
10mM
Purity
98.36
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
O=C1NC=CC2=C1C=C(NS(=O)(C3=CC=C(N4CC[C@@H](O)C4)S3)=O)C(F)=C2
Molecular Formula
C17H16FN3O4S2
Molecular Weight
409.46
References & Citations
[1]Fales KR, et al. Discovery of N- (6-Fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl) -5-[ (3R) -3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), a Potent and Selective Nonclassical Antifolate Aminoimidazole-4-carboxamide Ribonucleotide Formyltransferase (AICARFT) Inhibitor Effective at Tumor Suppression in a Cancer Xenograft Model. J Med Chem. 2017 Dec 14;60 (23) :9599-9616.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Alternative Products

CatalogName
RCD21199-01LSN 3213128
A19472-10LSN 3213128 10mg
A19472-100LSN 3213128 100mg
A19472-25LSN 3213128 25mg
A19472-50LSN 3213128 50mg
A19472-5LSN 3213128 5mg
A19472-1LSN 3213128 1mg

Popular Products