EN219

• Description :

  EN219 is a moderately selective synthetic covalent ligand against an N-terminal cysteine (C8) of RNF114 with an IC50 of 470 nM. EN219 inhibits RNF114-mediated autoubiquitination and p21 ubiquitination[1].

• Product Name Alternative :

  CD5789

• UNSPSC :

  12352005

• Hazard Statement :

  H301, H311, H331, H341

• Target :

  E1/E2/E3 Enzyme

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/en219.html

• Purity :

  99.21

• Solubility :

  DMSO : 65 mg/mL (ultrasonic)

• Smiles :

  ClCC(N1N=C(C2=CC=C(Br)C=C2)CC1C3=CC=C(Br)C=C3)=O

• Molecular Formula :

  C17H13Br2ClN2O

• Molecular Weight :

  456.56

• Precautions :

  H301, H311, H331, H341

• References & Citations :

  [1]Luo M, et al. Chemoproteomics-enabled discovery of covalent RNF114-based degraders that mimic natural product function. Cell Chem Biol. 2021 Apr 15;28 (4) :559-566.e15.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture and light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [380351-29-1]