Adiphenine

CAT: 0804-HY-121141Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-121141Size:1 Each

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Description

Adiphenine is a non-competitive inhibitor of nicotinic acetylcholine receptor (nAChR), with an IC50s of 1.9, 1.8, 3.7, and 6.3 μM for α1, α3β4, α4β2, and α4β4, respectively. Adiphenine has anticonvulsant effects[1][2][3].

CAS Number

64-95-9

UNSPSC

12352005

Target

NAChR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/adiphenine.html

Smiles

O=C(C(C1=CC=CC=C1)C2=CC=CC=C2)OCCN(CC)CC

Molecular Formula

C20H25NO2

Molecular Weight

311.42

References & Citations

[1]Gentry CL, et, al. Local anesthetics noncompetitively inhibit function of four distinct nicotinic acetylcholine receptor subtypes. J Pharmacol Exp Ther. 2001 Dec;299 (3) :1038-48. |[2]Spitzmaul, G., et al., The local anaesthetics proadifen and adiphenine inhibit nicotinic receptors by different molecular mechanisms. Br J Pharmacol, 2009. 157 (5) : p. 804-17. |[3]TANAKA K, et, al. Anticonvulsant properties of procaine, cocaine, adiphenine and related structures. Proc Soc Exp Biol Med. 1955 Oct;90 (1) :192-5. |[4]Michelot, J., et al., Adiphenine plasma levels and blood-brain barrier crossing in the rat. Eur J Drug Metab Pharmacokinet, 1985. 10 (4) : p. 273-8.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Alternative Products

Catalog	Name
T68940-01	Adiphenine
B1878-S	Adiphenine HCl
TRC-A291580-100G	Adiphenine Hydrochloride
T29659-01	Adiphenine methyl bromide

Adiphenine

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