Anti-Hu CD307c Purified
CAT:
270-11-858-C100
Size:
0.1 mg
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No

Anti-Hu CD307c Purified
- Background: CD307c is a type I transmembrane glycoprotein of the Fc receptor family. It contains both ITAM and ITIM motifs in its cytoplasmic domain. CD307c is expressed on the surface of NK cells, and T, Treg, B and plasma cell subsets. It seems to play a role in the regulation of immune response. Defects in CD307c function can result in autoimmune diseases, e.g. rheumatoid arthritis or systemic lupus erythematosus.
- Specifications: The mouse monoclonal antibody H5 recognizes an epitope within extracellular part of CD307c, a transmembrane glycoprotein expressed mainly on NK cells, and T and B cell subsets.
- CAS Number: 9007-83-4
- Certification: RUO
- Host: Mouse
- Species Reactivity: Human
- Immunogen: DNA-immunization followed by a boost with CD307c transfected cells
- Target Antigen: CD307c
- Isotype: IgG2b κ
- Clone: H5
- Applications: Flow cytometry: Recommended dilution: 1-4 μg/mL.
- Validated Applications: FC
- Concentration: 1 mg/mL
- Format: Purified
- Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- References & Citations: *Jourdan M, Robert N, Cren M, Thibaut C, Duperray C, Kassambara A, Cogné M, Tarte K, Klein B, Moreaux J: Characterization of human FCRL4-positive B cells. PLoS One. 2017 Jun 2112(6):e0179793., URL: https://www.ncbi.nlm.nih.gov/pubmed/28636654,*Wysocka M, Kossenkov AV, Benoit BM, Troxel AB, Singer E, Schaffer A, Kim B, Dentchev T, Nagata S, Ise T, Showe LC, Rook AH: CD164 and FCRL3 are highly expressed on CD4+CD26- T cells in Sézary syndrome patients. J Invest Dermatol. 2014 Jan134(1):229-236., URL: https://www.ncbi.nlm.nih.gov/pubmed/23792457,*Nagata S, Ise T, Pastan I: Fc receptor-like 3 protein expressed on IL-2 nonresponsive subset of human regulatory T cells. J Immunol. 2009 Jun 15182(12):7518-26, URL: https://www.ncbi.nlm.nih.gov/pubmed/19494275,
- Storage Conditions: Store at 2-8°C. Do not freeze.