Recombinant IL-21

• Gene Aliases:

  CX2, IL-17C

• Gene ID:

  27189

• Target:

  Interleukin 21 (IL-21) is a member of the common-gamma chain family of cytokines that are involved in immunoregulation. IL-21 is normally expressed by activated CD4+ T cells. The IL-21 receptor (IL-21R) activates the JAK/STAT signaling pathway and is expressed on T, B, and natural killer (NK) cells. Within the B cell lineage, IL-21 is a switch factor regulating IgG1 and IgG3 antibody production. IL-21 also cooperates with interleukin 4 (IL-4) for the production of multiple antibody classes in B cells. IL-21 has pleiotropic effects on the proliferation, differentiation, and effector functions of B, T, NK, and dendritic cells.

• Type:

  Protein

• Source:

  Genetically modified E.coli

• Sequence:

  MHKSSPQGPD RLLIRLRHLI DIVEQLKIYE NDLDPELLSA PQDVKGHCEH AAFACFQKAK LKPSNPGNNK TFIIDLVAQL RRRLPARRGG KKQKHIAKCP SCDSYEKRTP KEFLERLKWL LQKMIHQHLS

• Assay Protocol:

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Bioactivity:

  5Acceptance Criteria: //ED50≤10 ng/mL (≥1.0x105 units/mg) 5

• Format:

  Lyophilized// Sterile filtered aqueous solution containing 20mM sodium bicarbonate (pH 8.5)

• Reconstitution:

  Do not vortex.// Allow several minutes for complete reconstitution. For prolonged storage, dilute to working aliquots in a 0.1% BSA solution, store at -80C, and avoid repeated freeze/thaw cycles. Expiration Date: //12 months from date of receipt when stored at -20C to -80C as directed, 1 month when stored at 4C after reconstitution, and 3 months when stored at -20C to -80C after reconstitution.Expiration Date: //12 months from date of receipt when stored at -20C to -80C as directed, 1 month when stored at 4C after reconstitution, and 3 months when stored at -20C to -80C after reconstitution.

• Molecular Weight:

  15 kDa

• NCBI Gene Symbol:

  IL17C

• Protein Name:

  Interleukin-17C

• Gene Name URL:

  IL17C

• CAS Number:

  9000-83-3