RRAS2 Protein

CAT: 0247-OPPA02176-10UGSize: 10 µgDry Ice: NoHazardous: No
CAT#:0247-OPPA02176-10UGSize:10 µg
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Gene Aliases
NS12, TC21
Gene ID
22800
Accession Number
NP_036382.2
Reactivity
Human
Target
RRAS2 (RAS viral (r-ras) oncogene homolog 2) is a member of the Ras like GTPase family that cycle between GTP-bound active and GDP-bound inactive states at the cytoplasmic face of the plasma membrane. RRAS2 is a plasma membrane-associated GTP-binding protein with GTPase activity. RRAS2 is implicated in the pathogenesis of human cancers. Hence, overexpression of active RRAS2 in EpH4 cells induces tumorigenicity through the phosphoinositide 3-kinase, p38 MAPK, and mTOR pathways, as these cells lose their sensitivity to the normal growth inhibitory role of TGF-beta. RRAS2 might transduce growth inhibitory signals across the cell membrane, exerting its effect via an effector shared with the Ras proteins but in an antagonistic manner._x005F RRAS2 is ubiquitously present in all tissues examined, with the highest levels in the heart, placenta, and skeletal muscle. Moderate levels of RRAS2 are found in the lung and liver and low levels in the brain, kidney, and pancreas._x005F RRAS2 deficiencies are linked to ovarian cancer.
Type
Protein
Source
E. coli
Sequence
MGSSHHHHHHSSGLVPRGSH
Purification
The RRAS2 is purified by proprietary chromatographic techniques.
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Format
Liquid.// 20mM Tris-HCl, pH-8, 1mM DTT, 2 mM EDTA and 10% glycerol. Physical appearance:// Sterile filtered colorless solution.Physical appearance:// Sterile filtered colorless solution.
Molecular Weight
25.2 kDa
Notes
Formerly GWB-1DD700
Protein Length
Recombinant
NCBI Gene Symbol
RRAS2
Protein Name
Ras-related protein R-Ras2
Gene Name URL
RRAS2

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