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Recombinant Human Factor VIII Protein

CAT: 0247-OPPA01234-250IUSize: 250 IUDry Ice: NoHazardous: No
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CAT#:0247-OPPA01234-250IUSize:250 IU
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
9000-83-3
Gene Aliases
AHF, F8B, F8C, HEMA, FVIII, DXS1253E
Gene ID
2157
Accession Number
NP_000123.1
Reactivity
Human
Target
Coagulation factor VIII participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.
Type
Protein
Purification
Purified by proprietary chromatographic techniques.
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Bioactivity
The specific activity was found to be 7,058 IU/mg.
Format
Lyophilized.// 8 mg Tween-80, 112mM NaCl, 40 mg Mannitol, 10 mg Trehalose, 1 ng VWF and 4.2mM CaCl22
Reconstitution
2
Notes
Formerly GWB-B14900
Protein Length
Recombinant
NCBI Gene Symbol
FACTOR-VIII
Host or Source
Chinese Hamster Ovarian Cells (CHO)
Protein Name
Coagulation factor VIII
Gene Name URL
Factor-VIII

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