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THBS1 Protein

CAT: 0247-OPPA01205-2UGSize: 2 µgDry Ice: NoHazardous: No
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CAT#:0247-OPPA01205-2UGSize:2 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Gene Aliases
TSP, THBS, TSP1, TSP-1, THBS-1
Gene ID
7057
Accession Number
NP_003237.2
Reactivity
Human
Target
Thrombospondin-1 (TSP1) is a member of the Thrombospondin family and is encoded by the gene THBS1 which is a subunit of a disulfide-linked homotrimeric protein. Thrombospondin-1 is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Thrombospondin-1 can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. TSP1 has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. TSP1 has been shown to be a natural inhibitor of neovascularization and tumorigenesis in healthy tissue. TSP1 interacts with no less than 12 cell adhesion receptors, including CD36, *v integrins, *1 integrins, syndecan, and integrin-associated protein (IAP or CD47) . It also interacts with various proteases involved in angiogenesis, including plasminogen, urokinase, matrix metalloproteinase, thrombin, cathepsin, and elastase. Positive and negative modulation of endothelial cell adhesion, motility, and growth are attributed to TSP1. Recently, thrombospondin-1 was found to bind to the reelin receptors, ApoER2 and VLDLR, in so doing affecting neuronal migration in the rostral migratory stream. Recombinant Human THBS1 is glycosylated with N-linked sugars and produced using baculovirus vectors in insect cells. Recombinant Human THBS1 is Reactive with A4.1 anti-TSP mAb.
Type
Protein
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Concentration
87 ug/mL
Format
Liquid// 20mM Sodium Phosphate (pH 6.0) & 300mM NaCl Physical Appearance:// Sterile filtered clear solutionPhysical Appearance:// Sterile filtered clear solution
Reconstitution
Recombinant Human TSP should be stored between 2-8° C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA) . Please prevent freeze-thaw cycles.
Molecular Weight
140 kDa
Notes
Formerly GWB-ADB1FB
Protein Length
Recombinant
NCBI Gene Symbol
THBS1
Host or Source
Baculovirus Insect Cells
Protein Name
Thrombospondin-1
Gene Name URL
THBS1

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