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MMP 7 Protein

CAT: 0247-OPPA00793-5UGSize: 5 µgDry Ice: NoHazardous: No
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CAT#:0247-OPPA00793-5UGSize:5 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Gene Aliases
MMP-7, MPSL1, PUMP-1
Gene ID
4316
Accession Number
NP_002414.1
Reactivity
Human
Target
Matrix metalloproteinase-7 (MMP-7) also known as matrilysin and PUMP (EC 3.4.24.23) cleaves a number of substrates including collagen types IV and X, elastin, fibronectin, gelatin, laminin and proteoglycans. MMP-7 is closely related to the stromelysin family members but is encoded by a different gene. MMP-7 is the smallest of all the MMPs consisting of a pro-peptide domain and a catalytic domain. It lacks the hemopexin-like domain common to other members of the MMPs. MMP-7 is secreted as a 28 kDa proenzyme and can be activated in vitro by organomercurials and trypsin and in vivo by MMP-3 to a 18 kDa active MMP-7 enzyme. Once activated, MMP-7 can activate pro-MMP-1 and pro-MMP-9 but not pro-MMP-2. MMP-7 is widely expressed having been reported in elevated levels in cycling endometrium as well as in colorectal cancers and adenomas, hepatocellular carcinomas, rectal carcinomas, and approximately 50% of gliomas. Matrix Metalloproteinase-7 Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain.
Type
Protein
Applications
WB, ELISA
Purification
The MMP-7 is purified by proprietary chromatographic techniques.
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Concentration
1.9 mg/ml
Bioactivity
The specific activity was found to be 4.700 U/mg. One unit is defined as the digestion of 1 ug Azocoll/min at 37C.
Format
Liquid//10 mM HEPES (pH 7.4), 5 mM CaCl2 and 150 mM NaCl Physical Appearance: //Sterile clear solution2Physical Appearance: //Sterile clear solution
Reconstitution
Please prevent freeze-thaw cycles.//
Molecular Weight
19 kDa
Notes
Formerly GWB-70A582
Protein Length
Active|Recombinant
NCBI Gene Symbol
MMP 7
Host or Source
E.coli
Protein Name
Matrilysin
Gene Name URL
MMP 7

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