Manidipine

• Description:

  Manidipine is an orally active calcium channel antagonist. Manidipine regulates the expression of cytokines (IL-1β, IL-6) . Manidipine has a hypotensive effect. Manidipine can be used in the study of cardiovascular diseases (such as hypertension, myocardial ischemia-reperfusion injury, ventricular hypertrophy), kidney diseases (such as glomerular diseases), and epilepsy[1][2][3][4][5][6][7][8].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Calcium Channel; Interleukin Related

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation; Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Endocrinology; Neurological Disease; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/manidipine.html

• Purity:

  99.92

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C (C1=C (C) NC (C) =C (C (OC) =O) C1C2=CC=CC ([N+] ([O-]) =O) =C2) OCCN3CCN (C (C4=CC=CC=C4) C5=CC=CC=C5) CC3

• Molecular Formula:

  C35H38N4O6

• Molecular Weight:

  610.70

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Roth M, et al. Manidipine regulates the transcription of cytokine genes. Proc Natl Acad Sci U S A. 1992 May 1;89 (9) :4071-5.|[2]Huang S, et al. Manidipine inhibits endothelin-1-induced [Ca2+]i signaling but potentiates endothelin's effect on c-fos and c-jun induction in vascular smooth muscle and glomerular mesangial cells. Am Heart J. 1993 Feb;125 (2 Pt 2) :589-97.|[3]Costa S, et al. Manidipine reduces pro-inflammatory cytokines secretion in human endothelial cells and macrophages. Pharmacol Res. 2010 Sep;62 (3) :265-70.|[4]Yoshiyama M, et al. Effect of manidipine hydrochloride, a calcium antagonist, on isoproterenol-induced left ventricular hypertrophy. Jpn Circ J. 1998 Jan;62 (1) :47-52.|[5]Tojo A, et al. Effects of manidipine hydrochloride on the renal microcirculation in spontaneously hypertensive rats. J Cardiovasc Pharmacol. 1992 Dec;20 (6) :895-9.|[6]Rossoni G, et al. Combined simvastatin-manidipine protect against ischemia-reperfusion injury in isolated hearts from normocholesterolemic rats. Eur J Pharmacol. 2008 Jun 10;587 (1-3) :224-30.|[7]Haraguchi K, et al. Catalepsy induced by manidipine, a calcium channel blocker, in mice. J Pharm Pharmacol. 1996 Apr;48 (4) :429-32.|[8]Souza C N S, et al. 074— (SOA0068) Anticonvulsant activity of acute treatment with manidipine in pentylenetetrazole-and pilocarpine-induced seizure models in mice. Epilepsy & Behavior, 2014, 38: 214.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Citation 01:

  Biomed Pharmacother. 2025 Nov 12:193:118748.|bioRxiv. 2025 Nov 21:2025.11.20.689520.|Int Immunopharmacol. 2025 Apr 26:156:114735.

• CAS Number:

  89226-50-6