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PTGES3 Recombinant Protein (Human)

CAT: 0247-OPED00111-200UGSize: 200 µgDry Ice: NoHazardous: No
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CAT#:0247-OPED00111-200UGSize:200 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
9000-83-3
Gene Name
Prostaglandin E synthase 3
Gene Aliases
CPGES; cytosolic prostaglandin E synthase; cytosolic prostaglandin E2 synthase; Hsp90 co-chaperone; P23; progesterone receptor complex p23; prostaglandin E synthase 3; prostaglandin E synthase 3 (cytosolic) ; TEBP; telomerase-binding protein p23; unactive progesterone receptor, 23 kD.
Gene ID
10728
Accession Number
NP_067272.1
Reactivity
Homo sapiens|Human
Target
Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363) . Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419) . Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed:24711448) .
Type
Protein
Applications
WB
Purification
Purified by multi-step chromatography.
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Format
Liquid. In Dulbecco's PBS.
Reconstitution
Store at -80C
Molecular Weight
23 kDa
Protein Length
Recombinant
NCBI Gene Symbol
PTGES3
Host or Source
E. Coli
Protein Name
Prostaglandin E synthase 3
Gene Name URL
PTGES3
Nucleotide Accession Number
NM_021297.3