BAP1 Recombinant Protein (Human)

CAT: 0247-OPED00010-50UGSize: 50 µgDry Ice: NoHazardous: No
CAT#:0247-OPED00010-50UGSize:50 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
9000-83-3
Gene Name
BRCA1 associated protein 1
Gene Aliases
BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) ; BRCA1-associated protein 1; cerebral protein 6; cerebral protein-13; HUCEP-13; hucep-6; ubiquitin carboxyl-terminal hydrolase BAP1; UCHL2.
Gene ID
8314
Accession Number
NP_001073593.1
Reactivity
Homo sapiens|Human
Target
Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) . Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Able to mediate autodeubiquitination via intramolecular interactions to couteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration (PubMed:24703950) . Acts as a tumor suppressor.
Type
Protein
Purification
Purified by Ni-affinity chromatography.
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Format
Liquid. In 50mM Na-phosphate, pH 8.0, 300mM NaCl.
Reconstitution
Store at -80C
Molecular Weight
84 kDa
Protein Length
Recombinant
NCBI Gene Symbol
BAP1
Host or Source
E. Coli
Protein Name
Ubiquitin carboxyl-terminal hydrolase BAP1
Gene Name URL
BAP1
Nucleotide Accession Number
NM_001080124.1

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