SIRT3 Recombinant Protein

• Gene Name:

  Sirtuin 3

• Gene Aliases:

  2310003L23Rik; AI848213; mitochondrial protein lysine deacetylase; mSIR2L3; NAD-dependent deacetylase sirtuin-3; NAD-dependent protein deacetylase sirtuin-3; regulatory protein SIR2 homolog 3; Si; silent mating type information regulation 2, (S.cerevisiae, homolog) -like 3; Sir2l3; SIR2-like protein 3; SIRT3L mitochondrial.

• Gene ID:

  64384

• Accession Number:

  NP_001120823.1

• Reactivity:

  Mouse|Mus musculus

• Target:

  NAD-dependent protein deacetylase (PubMed:23835326, PubMed:17923681, PubMed:18794531, PubMed:21172655) . Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues (PubMed:23835326, PubMed:17923681, PubMed:18794531, PubMed:21172655) . Known targets include ACSS1, IDH, GDH, PDHA1, SOD2, LCAD, SDHA and the ATP synthase subunit ATP5O (PubMed:16790548, PubMed:18794531, PubMed:21172655) . Contributes to the regulation of the cellular energy metabolism (PubMed:23835326) . Important for regulating tissue-specific ATP levels (PubMed:18794531, PubMed:24252090) . In response to metabolic stress, deacetylates transcription factor FOXO3 and recruits FOXO3 and mitochondrial RNA polymerase POLRMT to mtDNA to promote mtDNA transcription (PubMed:23283301) .

• Conjugation:

  Unconjugated

• Type:

  Protein

• Source:

  E.coli

• Applications:

  Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot

• Assay Protocol:

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Concentration:

  200 ug/mL (prior to lyoph)

• Format:

  Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.

• Reconstitution:

  2°C to 8°C|-80°C

• Molecular Weight:

  29/16kDa

• Protein Length:

  Recombinant

• NCBI Gene Symbol:

  Sirt3

• Host or Source:

  E.coli

• Protein Name:

  NAD-dependent protein deacetylase sirtuin-3

• Gene Name URL:

  Sirt3

• CAS Number:

  9000-83-3

• Nucleotide Accession Number:

  NM_001127351.1