SH2D1A Recombinant Protein

• Gene Name:

  SH2 domain containing 1A

• Gene Aliases:

  Duncan disease homolog; Gm686; SAP; SH2 domain protein 1A; SH2 domain-containing protein 1A; signaling lymphocytic activation molecule-associated protein; T-cell signal transduction molecule SAP.

• Gene ID:

  20400

• Accession Number:

  NP_001300617.1

• Reactivity:

  Mouse|Mus musculus

• Target:

  Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2. However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1 (By similarity) . Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions (PubMed:22683124) . Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-mediated NK cell activation (PubMed:19648922) . In the context of NK cell-mediated cytotoxicity enhances conjugate formation with target cells (PubMed:22683124) . May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3.

• Conjugation:

  Unconjugated

• Type:

  Protein

• Source:

  E.coli

• Applications:

  Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot

• Assay Protocol:

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Concentration:

  200 ug/mL (prior to lyoph)

• Format:

  Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.

• Reconstitution:

  2°C to 8°C|-80°C

• Molecular Weight:

  16kDa

• Protein Length:

  Recombinant

• NCBI Gene Symbol:

  Sh2d1a

• Host or Source:

  E.coli

• Protein Name:

  SH2 domain-containing protein 1A

• Gene Name URL:

  Sh2d1a

• CAS Number:

  9000-83-3

• Nucleotide Accession Number:

  NM_001313688.1