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Resiniferatoxin

CAT: 0804-HY-N2333-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N2333-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Resiniferatoxin ((+) -Resiniferatoxin), is a selective agonist of transient receptor potential vanilloid 1 (TRPV1) receptor agonist. Resiniferatoxin can be isolated from the Euphorbia resinifera plant. Resiniferatoxin eliminates TRPV1+ primary sensory afferents and blunt cardiac sympathetic afferent reflex for a relatively long period[1][2].
CAS Number
57444-62-9
Product Name Alternative
(+) -Resiniferatoxin
UNSPSC
12352005
Hazard Statement
H301, H314, H315, H319, H335
Target
TRP Channel
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/resiniferatoxin.html
Purity
99.77
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
C[C@H]1[C@]23[C@](C=C(C[C@]4([C@@]3([H])C=C(C4=O)C)O)COC(CC5=CC(OC)=C(C=C5)O)=O)([H])[C@]6([H])[C@](C1)(O[C@](O2)(O6)CC7=CC=CC=C7)C(C)=C
Molecular Formula
C37H40O9
Molecular Weight
628.71
Precautions
H301, H314, H315, H319, H335
References & Citations
[1]Brown DC. Resiniferatoxin: The Evolution of the "Molecular Scalpel" for Chronic Pain Relief. Pharmaceuticals (Basel) . 2016;9 (3) :47. Published 2016 Aug 11.|[2]Wu Y, et al. Resiniferatoxin reduces ventricular arrhythmias in heart failure via selectively blunting cardiac sympathetic afferent projection into spinal cord in rats. Eur J Pharmacol. 2020;867:172836.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
Phase 3

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