Products for Research Use Only
RegisterLogin

PTPN22 Recombinant Protein

CAT: 0247-OPCD00401-10UGSize: 10 µgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0247-OPCD00401-10UGSize:10 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
9000-83-3
Gene Name
Protein tyrosine phosphatase non-receptor type 22
Gene Aliases
Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP; Lymphoid phosphatase; lymphoid-specific protein tyrosine phosphatase; LYP; LYP1; LYP2; PEP; PEST-domain phosphatase; protein tyrosine phosphatase, non-receptor type 22 (lymphoid) ; protein tyrosine phosphatase, non-receptor type 8; PTPN22.5; PTPN22.6; PTPN8; tyrosine-protein phosphatase non-receptor type 22.
Gene ID
26191
Accession Number
NP_001180360.1
Reactivity
Homo sapiens|Human
Target
Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules (PubMed:16461343, PubMed:18056643) . Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue (PubMed:21719704) . Dephosphorylates ZAP70 at its activating 'Tyr-493' residue (PubMed:16461343) . Dephosphorylates the immune system activator SKAP2 (PubMed:21719704) . Positively regulates toll-like receptor (TLR) -induced type 1 interferon production (PubMed:23871208) . Promotes host antiviral responses mediated by type 1 interferon (By similarity) . Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy (PubMed:23991106) .
Conjugation
Unconjugated
Type
Protein
Source
E.coli
Applications
Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Concentration
200 ug/mL (prior to lyoph)
Format
Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
Reconstitution
2°C to 8°C|-80°C
Molecular Weight
31kDa
Protein Length
Recombinant
NCBI Gene Symbol
PTPN22
Host or Source
E.coli
Protein Name
Tyrosine-protein phosphatase non-receptor type 22
Gene Name URL
PTPN22
Nucleotide Accession Number
NM_001193431.2

Related Products

CatalogName
OCOA10451-20UGPTPN22 Protein Lysate
OACD00713-1MLPTPN22 Antibody
OAAJ06881-100ULPTPN22 Antibody
OACD00714-1MLPTPN22 Antibody
OACD00714-100ULPTPN22 Antibody
OACD00713-100ULPTPN22 Antibody
ARP54896_P050-25ULPTPN22 Antibody - middle region
AAP54896-100UGPTPN22 Peptide - middle region (AAP54896)
ARP54896_P050PTPN22 Antibody - middle region (ARP54896_P050)
OPCD00395-50UGPTPN12 Recombinant Protein

Alternative Products

CatalogName
E30P69763BRecombinant Human PTPN22 Protein
RP222938PTPN22 Recombinant Protein (Rat)
RP025195PTPN22 Recombinant Protein (Human)
PPT-14837Human PTPN22 Recombinant Protein
RP165668PTPN22 Recombinant Protein (Mouse)
NBP1-81276PEPLyp/PTPN22 Recombinant Protein Antigen
YHD00901Recombinant Human PTPN22 Protein, N-His
PR16208Recombinant Human PTPN22 protein, N-6His
H00026191-Q01-10ugRecombinant Human Lyp/PTPN22 Protein - (Dry Ice)
MBS157029-01Recombinant Human PTPN22 protein, N-His Tag

Popular Products