RegisterLogin

MAPKAP1 Recombinant Protein

CAT: 0247-OPCA03186-100UGSize: 100 µgDry Ice: NoHazardous: No
CAT#:0247-OPCA03186-100UGSize:100 µg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
CAS Number
9000-83-3
Gene Name
MAPK associated protein 1
Gene Aliases
JC310; MEKK2-interacting protein 1; MIP1; mitogen-activated protein kinase 2-associated protein 1; mitogen-activated protein kinase associated protein 1; mSIN1; ras inhibitor MGC2745; SAPK-interacting protein 1; SIN1; SIN1b; SIN1g; stress-activated map kinase interacting protein 1; Stress-activated map kinase-interacting protein 1; stress-activated protein kinase-interacting 1; target of rapamycin complex 2 subunit MAPKAP1; TORC2 subunit MAPKAP1.
Gene ID
79109
Accession Number
NP_001006618.1
Reactivity
Homo sapiens|Human
Target
Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex.
Type
Protein
Source
E.coli
Sequence
AFLDNPTIILAHIRQSHVTSDDTGMCEMVLIDHDVDLEKIHPPSMPGDSGSEIQGSNGETQGYVYAQSVDITSSWDFGIRRRSNTAQRLERLRKERQNQIKCKNIQWKERNSKQSAQELKSLFEKKSLKEKPPISGKQSILSVRLEQCPLQLNNPFNEYSKFDGKGHVGTTATKKIDVYLPLHSSQDRLLPMTVVTMASARVQDLIGLICWQYTSEGREPKLNDNVSAYCLHIAEDDGEVDTDFPPLDSNEPIHKFGFSTLALVEKYSSPGLTSKESLFVRINAAHGFSLIQVDNTKVTMKEILLKAVKRRKGSQKVSGPQYRLEKQSEPNVAVDLDSTLESQSAWEFCLVRENSSRADGVFEEDSQIDIATVQDMLSSHHYKSFKVSMIHRLRFTTDVQLGISGDKVEIDPVTNQKASTKFWIKQKPISIDSDLLCACDLAEEKSPSHAIFKLTYLSNHDYKHLYFESDAATVNEIVLKVNYILESRASTARADYFAQKQRKLNRRTSFSFQKEKKSGQQ
Purification
Affinity purified using IMAC.
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Concentration
Varies by lot. See vial for exact concentration.
Format
Liquid or Lyophilized powder
Reconstitution
-20°C or -80°C
Molecular Weight
75 kDa
Protein Length
Recombinant
NCBI Gene Symbol
MAPKAP1
Host or Source
Human
Protein Name
Target of rapamycin complex 2 subunit MAPKAP1
Gene Name URL
MAPKAP1
Nucleotide Accession Number
NM_001006617.1

Related Products

CatalogName
OCOA08374-20UGMAPKAP1 Protein Lysate
OCOA16725-20UGMAPKAP1 Protein Lysate
OCOA16807-20UGMAPKAP1 Protein Lysate
OCOA00337-20UGMAPKAP1 Protein Lysate
OAPB00506-100UGMAPKAP1 Antibody
OAPB00507-100UGMAPKAP1 Antibody
ARP97174_P050-25ULMAPKAP1 Antibody - middle region
ARP97174_P050Mapkap1 Antibody Middle region
OAPB00506-100UG-BiotinMAPKAP1 Antibody : Biotin (OAPB00506-Biotin)
OAPB00507-100UG-BiotinMAPKAP1 Antibody : Biotin (OAPB00507-Biotin)

Alternative Products

CatalogName
RP210836MAPKAP1 Recombinant Protein (Rat)
RP149390MAPKAP1 Recombinant Protein (Mouse)
RP018808MAPKAP1 Recombinant Protein (Human)
E30P4558Recombinant Human MAPKAP1 Protein
TMPH-04147-01MAPKAP1 Protein, Human, Recombinant (His)
TP508361Mapkap1 (NM_177345) Mouse Recombinant Protein
NBP1-89568PEPSin1/MAPKAP1 Recombinant Protein Antigen
TP311745MSIN1 (MAPKAP1) (NM_001006617) Human Recombinant Protein
GTR04558342-01Recombinant Mitogen Activated Protein Kinase Associated Protein 1 (MAPKAP1)
RPU58031-01Recombinant Human Mitogen Activated Protein Kinase Associated Protein 1 (MAPKAP1)

Popular Products