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Humulone

CAT: 0804-HY-N6084-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N6084-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Humulone (α-Lupulic acid), a prenylated phloroglucinol derivative, is a potent cyclooxygenase-2 (COX-2) inhibitor. Humulone acts as a positive modulator of GABAA receptor at low micromolar concentrations. Humulone is an inhibitor of bone resorption. Humulone possesses antioxidant, anti-angiogenic and apoptosis-inducing properties[1][2][3].
CAS Number
26472-41-3
Product Name Alternative
α-Lupulic acid
UNSPSC
12352211
Target
Apoptosis; COX; GABA Receptor
Type
Natural Products
Related Pathways
Apoptosis; Immunology/Inflammation; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/humulone.html
Purity
99.46
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C/C(C)=C/C[C@@]1(C(C(C(CC(C)C)=O)=C(O)C(C/C=C(C)\C)=C1O)=O)O
Molecular Formula
C21H30O5
Molecular Weight
362.46
References & Citations
[1]K Yamamoto, et al. Suppression of cyclooxygenase-2 gene transcription by humulon of beer hop extract studied with reference to glucocorticoid. FEBS Lett. 2000 Jan 14;465 (2-3) :103-6.|[2]Ali Y Benkherouf, et al. Humulone Modulation of GABA A Receptors and Its Role in Hops Sleep-Promoting Activity. Front Neurosci. 2020 Oct 14;14:594708.|[3]Jung-Chul Lee, et al. Humulone inhibits phorbol ester-induced COX-2 expression in mouse skin by blocking activation of NF-kappaB and AP-1: IkappaB kinase and c-Jun-N-terminal kinase as respective potential upstream targets. Carcinogenesis. 2007 Jul;28 (7) :1491-8.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
COX-2

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