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Glabridin

CAT: 0804-HY-N0393-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0393-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Glabridin is a natural isoflavan from Glycyrrhiza glabra L., binds to and activates PPARγ, with an EC50 of 6115 nM. Glabridin exhibits antioxidant, anti-bacterial, anti-nephritic, anti-diabetic, anti-fungal, antitumor, anti-inflammatory, antiosteoporotic, cardiovascular protective, neuroprotective and radical scavenging activities[1][2].
CAS Number
59870-68-7
UNSPSC
12352005
Hazard Statement
H302+H312+H332
Target
Bacterial; PPAR; Reactive Oxygen Species (ROS)
Type
Natural Products
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection; Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Glabridin.html
Purity
99.98
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
OC1=CC=C([C@H]2CC3=CC=C4C(C=CC(C)(C)O4)=C3OC2)C(O)=C1
Molecular Formula
C20H20O4
Molecular Weight
324.37
Precautions
H302+H312+H332
References & Citations
[1]Rebhun JF, et al. Identification of glabridin as a bioactive compound in licorice (Glycyrrhiza glabra L.) extract that activates human peroxisome proliferator-activated receptor gamma (PPARγ) . Fitoterapia. 2015 Oct;106:55-61.|[2]Chen CT, et al. Glabridin induces apoptosis and cell cycle arrest in oral cancer cells through the JNK1/2 signaling pathway. Environ Toxicol. 2018 Jun;33 (6) :679-685.|[3]El-Ashmawy NE, et al. Downregulation of iNOS and elevation of cAMP mediate the anti-inflammatory effect of glabridin in rats with ulcerative colitis. Inflammopharmacology. 2018 Apr;26 (2) :551-559.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
PPARγ

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