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LY3177833

CAT: 0804-HY-100023-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100023-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LY3177833 (Example 4) is an orally active CDC7 and pMCM2 inhibitor with IC50 values of 3.3 nM and 290 nM, respectively. LY3177833 is a senescence inducer[1][2].
CAS Number
1627696-51-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/LY3177833.html
Purity
99.48
Solubility
DMSO : ≥ 30 mg/mL
Smiles
O=C1N[C@@](C)(C2=NC=NC=C2F)C3=C1C=C(C4=CNN=C4)C=C3
Molecular Formula
C16H12FN5O
Molecular Weight
309.30
Precautions
H302, H315, H319
References & Citations
[1]Robert Dean Dally, et al. CDC7 Inhibitors. Patent WO2014143601A1.|[2]Li X, et al. First-generation species-selective chemical probes for fluorescence imaging of human senescence-associated β-galactosidase. Chem Sci. 2020 Jun 17;11 (28) :7292-7301.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDC

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