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LX2343

CAT: 0804-HY-111383-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-111383-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LX2343 is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM. LX2343 acts as a non-ATP competitive PI3K inhibitor with an IC50 of 15.99±3.23 μM. LX2343 stimulates autophagy in its promotion of Aβ clearance.
CAS Number
333745-53-2
UNSPSC
12352005
Target
Amyloid-β; Autophagy; Beta-secretase; PI3K
Type
Reference compound
Related Pathways
Autophagy; Neuronal Signaling; PI3K/Akt/mTOR
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/LX2343.html
Purity
99.80
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(NC1=CC=C(OCO2)C2=C1)CN(C3=CC(Cl)=CC=C3OC)S(=O)(C4=CC=CC=C4)=O
Molecular Formula
C22H19ClN2O6S
Molecular Weight
474.91
References & Citations
[1]Guo XD, et al. Small molecule LX2343 ameliorates cognitive deficits in AD model mice by targeting both amyloid β production and clearance. Acta Pharmacol Sin. 2016 Sep;37 (10) :1281-1297.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BACE1; PI3K

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S6503-01LX2343
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A20288-5LX2343 5mg
A20288-200LX2343 200mg
A20288-2LX2343 2mg
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