Human CD16 Antibody

• Gene Name:

  Low affinity immunoglobulin gamma Fc region receptor III-A

• Gene Aliases:

  CD16, FCG3, CD16A, FCGR3, IGFR3, IMD20, FCR-10, FCRIII, FCGRIII, FCRIIIA

• Gene ID:

  2214

• Accession Number:

  NP_000560.6

• Reactivity:

  Human

• Immunogen:

  Mononuclear cells from a prolymphocytic B-leukemia

• Target:

  This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

• Clonality:

  Monoclonal

• Clone:

  GRM1

• Conjugation:

  Unconjugated

• Type:

  Monoclonal Antibody

• Applications:

  FC, IHC-F, IP, WB, CMCD

• Assay Protocol:

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Concentration:

  0.1 mg/mL

• Dilution:

  6 cells 10 uL/106 cells 10 uL/106 cells 10 uL/106 cells 10 uL/106 cells6666

• Reconstitution:

  Store at 2-8C

• Fragment:

  IgG2a

• Specificity:

  CD16

• NCBI Gene Symbol:

  FCGR3A

• Host or Source:

  Mouse

• Protein Name:

  Low affinity immunoglobulin gamma Fc region receptor III-A

• Gene Name URL:

  FCGR3A

• CAS Number:

  9007-83-4

• Nucleotide Accession Number:

  NM_000569.7