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Human Lambda Antibody

CAT: 0247-OASB00893-500UGSize: 0.5 mgDry Ice: NoHazardous: No
CAT#:0247-OASB00893-500UGSize:0.5 mg
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PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
9007-83-4
Gene Name
Ig lambda-1 chain C regions
Gene Aliases
IGL@, IGLC6
Gene ID
3535
Reactivity
Human
Target
Immunoglobulins recognize foreign antigens and initiate immune responses such as phagocytosis and the complement system. Each immunoglobulin molecule consists of two identical heavy chains and two identical light chains. There are two classes of light chains, kappa and lambda. This region represents the germline organization of the lambda light chain locus. The locus includes V (variable), J (joining), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a single V segment with a J segment; the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes. Several V segments and three C segments are known to be incapable of encoding a protein and are considered pseudogenes. The locus also includes several non-immunoglobulin genes, many of which are pseudogenes or are predicted by automated computational analysis or homology to other species.
Clonality
Monoclonal
Clone
JDC-12
Conjugation
Unconjugated
Type
Monoclonal Antibody
Applications
FC, WB, IP
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Concentration
0.5 mg/mL
Dilution
6 cells 6 cells 6 cells 1:500-1:1,000 1:1,000-1:2,000 1:1,000-1:2,0006 cells 6 cells 1:500-1:1,000 1:1,000-1:2,000 1:1,000-1:2,0006 cells 1:500-1:1,000 1:1,000-1:2,000 1:1,000-1:2,000
Reconstitution
Store at 2-8C
Notes
Formerly GWB-F2A8E6
Fragment
IgG1
Specificity
Lambda
NCBI Gene Symbol
IGL
Host or Source
Mouse
Protein Name
Ig lambda-6 chain C region
Gene Name URL
IGL

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