Human IgM Antibody

CAT: 0247-OASB00858-500UGSize: 0.5 mgDry Ice: NoHazardous: No
CAT#:0247-OASB00858-500UGSize:0.5 mg
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CAS Number
9007-83-4
Gene Name
Ig mu chain C region
Gene Aliases
MU, VH, AGM1
Gene ID
3507
Reactivity
Human
Target
Immunoglobulins (Ig) are the antigen recognition molecules of B cells. An Ig molecule is made up of 2 identical heavy chains and 2 identical light chains (see MIM 147200) joined by disulfide bonds so that each heavy chain is linked to a light chain and the 2 heavy chains are linked together. Each Ig heavy chain has an N-terminal variable (V) region containing the antigen-binding site and a C-terminal constant (C) region, encoded by an individual C region gene, that determines the isotype of the antibody and provides effector or signaling functions. The heavy chain V region is encoded by 1 each of 3 types of genes: V genes (see MIM 147070), joining (J) genes (see MIM 147010), and diversity (D) genes (see MIM 146910) . The C region genes are clustered downstream of the V region genes within the heavy chain locus on chromosome 14. The IGHM gene encodes the C region of the mu heavy chain, which defines the IgM isotype. Naive B cells express the transmembrane forms of IgM and IgD (see IGHD; MIM 1471770) on their surface. During an antibody response, activated B cells can switch to the expression of individual downstream heavy chain C region genes by a process of somatic recombination known as isotype switching. In addition, secreted Ig forms that act as antibodies can be produced by alternative RNA processing of the heavy chain C region sequences. Although the membrane forms of all Ig isotypes are monomeric, secreted IgM forms pentamers, and occasionally hexamers, in plasma (summary by Janeway et al., 2005) .[supplied by OMIM, Aug 2010]
Clonality
Monoclonal
Clone
UHB
Conjugation
Unconjugated
Type
Monoclonal Antibody
Applications
FC, WB, STIM
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Concentration
0.5 mg/mL
Dilution
6 cells 6 cells 6 cells 1:500-1:1,000 1:4,000-1:8,000 1:5,000-1:10,0006 cells 6 cells 1:500-1:1,000 1:4,000-1:8,000 1:5,000-1:10,0006 cells 1:500-1:1,000 1:4,000-1:8,000 1:5,000-1:10,000
Reconstitution
Store at 2-8C
Notes
Formerly GWB-474C1D
Fragment
IgG3
Specificity
IgM
NCBI Gene Symbol
IGHM
Host or Source
Mouse
Gene Name URL
IGHM

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