CHAT Antibody

CAT: 0247-OAPC00231-100ULSize: 100 µLDry Ice: NoHazardous: No
CAT#:0247-OAPC00231-100ULSize:100 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
9007-83-4
Gene Name
Choline O-acetyltransferase
Gene Aliases
CMS6, CMS1A, CMS1A2, CHOACTASE
Gene ID
1103
Reactivity
Human, Mouse, Chicken, Guinea Pig
Immunogen
Native choline acetyltransferase purifed from human placenta
Target
Choline acetyltransferase is a neuronal enzyme which catalyzes the reaction between Acetyl CoA and choline resulting in the formation of acetylcholine. It is therefore found primarily in cholinergic neurons making it a valuable marker for diseases associated with decreased cholinergic function such as Schizophrenia, Alzheimer disease (AD) and Down syndrome (Holt et al. 1999) . Decreased choline acetyltransferase activity in particular has been shown in Schizophrenic subjects (Karson et al 1993) . It has furthermore been demonstrated that in patients with AD, there are significantly lower levels of cortical ChAT that correlate with severity of the disease as measured by loss of neuropsychological function (Baskin et al. 1999) .
Clonality
Polyclonal
Type
Polyclonal Antibody
Applications
WB, IHC
Purification
Affinity Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Format
100 ul in in PBS + 5 mg/ml BSA + 0.2% NaN3.
Reconstitution
For long term storage -20C is recommended. Stable at -20C for at least 1 year. Avoid freeze/thaw cycles.
Molecular Weight
70 kDa
Specificity
Specific for ~70k ChAT protein.
NCBI Gene Symbol
CHAT
Host or Source
Goat
Gene Name URL
CHAT

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