ORAI1 Antibody

• Gene Name:

  ORAI calcium release-activated calcium modulator 1

• Gene Aliases:

  Calcium release-activated calcium channel protein 1; calcium release-activated calcium modulator 1; CRACM1; IMD9; ORAT1; protein orai-1; TAM2; TMEM142A; transmembrane protein 142A.

• Gene ID:

  84876

• Reactivity:

  Human|Mouse|Rat

• Immunogen:

  Mouse monoclonal ORAI1 antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human ORAI1.

• Target:

  Ca (2+) release-activated Ca (2+) (CRAC) channel subunit which mediates Ca (2+) influx following depletion of intracellular Ca (2+) stores and channel activation by the Ca (2+) sensor, STIM1 (PubMed:16582901, PubMed:16645049, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:19249086, PubMed:23307288, PubMed:24351972, PubMed:24591628, PubMed:28219928) . CRAC channels are the main pathway for Ca (2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT (PubMed:16582901) .

• Clonality:

  Monoclonal

• Conjugation:

  Unconjugated

• Type:

  Monoclonal Antibody

• Applications:

  Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry-Paraffin|Western blot

• Purification:

  Protein A Purified

• Assay Protocol:

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Concentration:

  1 mg/ml

• Homology:

  Human; Mouse; Rat

• Format:

  Liquid. ORAI1 Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.

• Reconstitution:

  ORAI1 monoclonal antibody can be stored at 4C, stable for one year.

• Molecular Weight:

  Predicted: 33 kDa Observed: 56 kDa

• NCBI Gene Symbol:

  ORAI1

• Protein Name:

  Calcium release-activated calcium channel protein 1

• Gene Name URL:

  ORAI1

• CAS Number:

  9007-83-4