Products for Research Use Only
RegisterLogin

RIPK1 Antibody

CAT: 0247-OAPB00958-100UGSize: 0.1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0247-OAPB00958-100UGSize:0.1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
9007-83-4
Gene Name
Receptor interacting serine/threonine kinase 1
Gene Aliases
AIEFL; cell death protein RIP; IMD57; receptor (TNFRSF) -interacting serine-threonine kinase 1; receptor-interacting protein 1; receptor-interacting protein kinase 1; receptor-interacting serine/threonine-protein kinase 1; RIP; RIP1; RIP-1; serine/threonine-protein kinase RIP.
Gene ID
8737
Accession Number
https://www.ncbi.nlm.nih.gov/protein/NP_003795
Reactivity
Human|Mouse|Rat
Immunogen
RIPK1 antibody was raised against a 15 amino acid synthetic peptide from near the amino terminus of human RIPK1. The immunogen is located within amino acids 180 - 230 of RIPK1.
Target
Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry-Paraffin|Western blot
Purification
Affinity Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Concentration
1 mg/ml
Homology
Human; Mouse; Rat
Format
Liquid. RIPK1 Antibody is supplied in PBS containing 0.02% sodium azide.
Reconstitution
RIPK1 antibody can be stored at 4C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
NCBI Gene Symbol
RIPK1
Host or Source
Rabbit
Protein Name
Receptor-interacting serine/threonine-protein kinase 1|receptor-interacting serine/threonine-protein kinase 1 isoform 1 [Homo sapiens]
Gene Name URL
RIPK1

Related Products

CatalogName
OPCD06697-50UGRIPK1 Recombinant Protein
OPCD06697-10UGRIPK1 Recombinant Protein
OPCD06697-200UGRIPK1 Recombinant Protein
OCOA01139-20UGRIPK1 Protein Lysate
OPCD00638-10UGRIPK1 Recombinant Protein
OPCD00638-200UGRIPK1 Recombinant Protein
OPCD00638-50UGRIPK1 Recombinant Protein
OKDD00507-96WRIPK1 ELISA Kit (Human)
OKCD00437-96WRIPK1 ELISA Kit (Rat)
OKCD00436-96WRIPK1 ELISA Kit (Human)

Alternative Products

CatalogName
70R-21675RIPK1 antibody

Popular Products