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RSPO1 Antibody

CAT: 0247-OAPB00890-100UGSize: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0247-OAPB00890-100UGSize:0.1 mg
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Description
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CAS Number
9007-83-4
Gene Name
R-spondin 1
Gene Aliases
CRISTIN3; roof plate-specific spondin-1; RSPO; R-spondin homolog; R-spondin-1.
Gene ID
284654
Accession Number
https://www.ncbi.nlm.nih.gov/protein/NP_001033722
Reactivity
Human|Mouse|Rat
Immunogen
Anti-RSPO1 antibody (5171) was raised against a peptide corresponding to 16 amino acids near the amino terminus of human RSPO1. The immunogen is located within the first 50 amino acids of RSPO1.
Target
Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination. Regulates Wnt signaling by antagonizing DKK1/KREM1-mediated internalization of LRP6 through an interaction with KREM1 (PubMed:17804805) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry-Paraffin|Western blot
Purification
Affinity Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Concentration
1 mg/ml
Homology
Human; Mouse; Rat
Format
Liquid. RSPO1 Antibody is supplied in PBS containing 0.02% sodium azide.
Reconstitution
2°C to 8°C
Molecular Weight
Predicted: 29kD Observed: 36 kD (Post-modification: 1 N-linked glycosylation)
NCBI Gene Symbol
RSPO1
Host or Source
Rabbit
Protein Name
R-spondin-1|R-spondin-1 isoform 1 precursor [Homo sapiens]
Gene Name URL
RSPO1

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