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XBP1 Antibody

CAT: 0247-OAPB00381-100UGSize: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0247-OAPB00381-100UGSize:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
9007-83-4
Gene Name
X-box binding protein 1
Gene Aliases
Tax-responsive element-binding protein 5; TREB5; TREB-5; X-box-binding protein 1; XBP-1; XBP2.
Gene ID
7494
Accession Number
NP_001073007.1NP_005071.2
Reactivity
Bovine|Human|Mouse|Rat
Immunogen
Anti-XBP-1 antibody (3687) was raised against a peptide corresponding to 17 amino acids near the amino terminus of human XBP-1. The immunogen is located within amino acids 40 - 90 of XBP-1.
Target
Functions as a transcription factor during endoplasmic reticulum (ER) stress by regulating the unfolded protein response (UPR) . Required for cardiac myogenesis and hepatogenesis during embryonic development, and the development of secretory tissues such as exocrine pancreas and salivary gland (By similarity) . Involved in terminal differentiation of B lymphocytes to plasma cells and production of immunoglobulins (PubMed:11460154) . Modulates the cellular response to ER stress in a PIK3R-dependent manner (PubMed:20348923) . Binds to the cis-acting X box present in the promoter regions of major histocompatibility complex class II genes (PubMed:8349596) . Involved in VEGF-induced endothelial cell (EC) proliferation and retinal blood vessel formation during embryonic development but also for angiogenesis in adult tissues under ischemic conditions. Functions also as a major regulator of the UPR in obesity-induced insulin resistance and type 2 diabetes for the management of obesity and diabetes prevention (By similarity) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
Enzyme-linked immunosorbent assay|Immunocytochemistry|Immunofluorescence|Immunohistochemistry-Paraffin|Western blot
Purification
Affinity Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Concentration
1 mg/ml
Homology
Human; Mouse
Format
Liquid. XBP-1 Antibody is supplied in PBS containing 0.02% sodium azide.
Reconstitution
XBP-1 antibody can be stored at 4C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Molecular Weight
Predicted: 28/40kD Observed: 28/40 kD
NCBI Gene Symbol
XBP1
Host or Source
Rabbit
Protein Name
X-box-binding protein 1
Gene Name URL
XBP1
Nucleotide Accession Number
NM_001079539.1NM_005080.3

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