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AGAP2 Antibody

CAT: 0247-OAPB00239-100UGSize: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0247-OAPB00239-100UGSize:0.1 mg
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Description
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CAS Number
9007-83-4
Gene Name
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
Gene Aliases
Arf GAP with GTP-binding protein-like, ANK repeat and PH domains 2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2; centaurin, gamma 1; Centaurin-gamma-1; CENTG1; GGAP2; GTP-binding and GTPase activating protein 2; GTP-binding and GTPase-activating protein 2; phosphatidylinositol 3-kinase enhancer; phosphoinositide 3-kinase enhancer; PIKE.
Gene ID
116986
Accession Number
https://www.ncbi.nlm.nih.gov/protein/AAM97540
Reactivity
Human|Mouse|Rat
Immunogen
PIKE antibody was raised against a peptide corresponding to 15 amino acids near the C-terminus of human PIKE. The immunogen is located within the last 50 amino acids of PIKE.
Target
GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1) -dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
Enzyme-linked immunosorbent assay|Immunohistochemistry-Paraffin|Western blot
Purification
Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Concentration
1 mg/ml
Homology
Human; Mouse
Format
Liquid. PIKE Antibody is supplied in PBS containing 0.02% sodium azide.
Reconstitution
PIKE antibody can be stored at 4C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Notes
Formerly GWB-27C96A
Specificity
Anti-PIKE will detect both PIKE-L and PIKE-A isoforms.
NCBI Gene Symbol
AGAP2
Host or Source
Rabbit
Protein Name
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2|PI 3-kinase enhancer long isoform [Homo sapiens]
Gene Name URL
AGAP2
Nucleotide Accession Number
NM_001122772.2NM_014770.3

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