AICDA Antibody

• Description :

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• Gene Name :

  Activation induced cytidine deaminase

• Gene Aliases :

  Activation-induced cytidine deaminase; AID; ARP2; CDA2; cytidine aminohydrolase; epididymis secretory protein Li 284; HEL-S-284; HIGM2; integrated into Burkitt's lymphoma cell line Ramos; single-stranded DNA cytosine deaminase.

• Gene ID :

  57379

• Accession Number :

  https://www.ncbi.nlm.nih.gov/protein/AAM95402

• Reactivity :

  Bovine|Human|Mouse

• Immunogen :

  AID antibody was raised against a peptide corresponding to 14 amino acids near the carboxy terminus of human AID. The immunogen is located within the last 50 amino acids of AID.

• Target :

  Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses (PubMed:18722174, PubMed:21385873, PubMed:21518874, PubMed:27716525) . May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation (PubMed:21496894) .

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Polyclonal Antibody

• Applications :

  Enzyme-linked immunosorbent assay|Immunocytochemistry|Immunofluorescence|Western blot

• Purification :

  Affinity Purified

• Assay Protocol :

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Concentration :

  1 mg/ml

• Homology :

  Bovine (100%)

• Format :

  Liquid. AID Antibody is supplied in PBS containing 0.02% sodium azide.

• Reconstitution :

  AID antibody can be stored at 4C for three months and -20C for up to one year. As with all antibodies care should be taken to avoid repeated freeze/thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Molecular Weight :

  Predicted: 22 kDa Observed: 25 kDa

• Notes :

  Formerly GWB-847AB0

• NCBI Gene Symbol :

  AICDA

• Host or Source :

  Rabbit

• Protein Name :

  AID, partial [Homo sapiens]|Single-stranded DNA cytosine deaminase

• Gene Name URL :

  AICDA

• CAS Number :

  9007-83-4

• Nucleotide Accession Number :

  NM_020661.2