MPRIP Antibody

CAT: 0247-OAPB00109-100UGSize: 0.1 mgDry Ice: NoHazardous: No
CAT#:0247-OAPB00109-100UGSize:0.1 mg
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Description
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CAS Number
9007-83-4
Gene Name
Receptor-interacting serine-threonine kinase 3
Gene Aliases
2610528K09Rik; AW107945; mRIP3; R; receptor interacting protein 3; Receptor-interacting protein 3; receptor-interacting serine/threonine-protein kinase 3; Rip3; RIP-3; RIP-like protein kinase 3.
Gene ID
56532
Accession Number
https://www.ncbi.nlm.nih.gov/protein/AAF03133
Reactivity
Human|Mouse|Rat
Immunogen
Anti-RIP3 antibody (2283) was raised against a peptide corresponding to 14 amino acids near the carboxy terminus of murine RIP3. The immunogen is located within the last 50 amino acids of RIP3.
Target
Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry-Paraffin|Immunoprecipitation|Western blot
Purification
Affinity Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Concentration
1 mg/ml
Homology
Mouse; Rat
Format
Liquid. RIP3 Antibody is supplied in PBS containing 0.02% sodium azide.
Reconstitution
2°C to 8°C
Molecular Weight
Predicted: 53kD for mouse RIP3 and 57kD for human RIP3 Observed: 53kD for mouse RIP3 and 57kD for human RIP3
Notes
Formerly GWB-699E61
NCBI Gene Symbol
Ripk3
Host or Source
Rabbit
Protein Name
Receptor interacting protein 3 [Mus musculus]|Receptor-interacting serine/threonine-protein kinase 3
Gene Name URL
Ripk3
Nucleotide Accession Number
NM_015134.3NM_201274.3XM_005256564.3

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