MPRIP Antibody

• Description:

  Click here to learn more about Aviva's By-Request Conjugation Service.//here

• Gene Name:

  Receptor-interacting serine-threonine kinase 3

• Gene Aliases:

  2610528K09Rik; AW107945; mRIP3; R; receptor interacting protein 3; Receptor-interacting protein 3; receptor-interacting serine/threonine-protein kinase 3; Rip3; RIP-3; RIP-like protein kinase 3.

• Gene ID:

  56532

• Accession Number:

  https://www.ncbi.nlm.nih.gov/protein/AAF03133

• Reactivity:

  Human|Mouse|Rat

• Immunogen:

  Anti-RIP3 antibody (2283) was raised against a peptide corresponding to 14 amino acids near the carboxy terminus of murine RIP3. The immunogen is located within the last 50 amino acids of RIP3.

• Target:

  Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry-Paraffin|Immunoprecipitation|Western blot

• Purification:

  Affinity Purified

• Assay Protocol:

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Concentration:

  1 mg/ml

• Homology:

  Mouse; Rat

• Format:

  Liquid. RIP3 Antibody is supplied in PBS containing 0.02% sodium azide.

• Reconstitution:

  2°C to 8°C

• Molecular Weight:

  Predicted: 53kD for mouse RIP3 and 57kD for human RIP3 Observed: 53kD for mouse RIP3 and 57kD for human RIP3

• Notes:

  Formerly GWB-699E61

• NCBI Gene Symbol:

  Ripk3

• Host or Source:

  Rabbit

• Protein Name:

  Receptor interacting protein 3 [Mus musculus]|Receptor-interacting serine/threonine-protein kinase 3

• Gene Name URL:

  Ripk3

• CAS Number:

  9007-83-4

• Nucleotide Accession Number:

  NM_015134.3NM_201274.3XM_005256564.3