Products for Research Use Only
RegisterLogin

ACIN1 Antibody

CAT: 0247-OAPB00085-100UGSize: 0.1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0247-OAPB00085-100UGSize:0.1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
9007-83-4
Gene Name
Apoptotic chromatin condensation inducer 1
Gene Aliases
ACINUS; ACN; apoptotic chromatin condensation inducer in the nucleus; fSAP152; functional spliceosome-associated protein 152.
Gene ID
22985
Accession Number
https://www.ncbi.nlm.nih.gov/protein/AAD56724
Reactivity
Human|Mouse
Immunogen
Acinus antibody was raised against a peptide corresponding to amino acids near the C-terminus of the cleaved active peptide p17, which are identical to those of mouse Acinus. The immunogen is located within amino acids 1050 - 1100 of Acinus.
Target
Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes) ; specifically inhibits formation of proapoptotic isoforms such as Bcl-X (S) ; the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
Enzyme-linked immunosorbent assay|Immunocytochemistry|Immunofluorescence|Western blot
Purification
Affinity Purified
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Concentration
1 mg/ml
Homology
Human
Format
Liquid. Acinus Antibody is supplied in PBS containing 0.02% sodium azide.
Reconstitution
Acinus antibody can be stored at 4C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Molecular Weight
220 kDa
Notes
Formerly GWB-E66F7C
NCBI Gene Symbol
ACIN1
Host or Source
Rabbit
Protein Name
AcinusL [Homo sapiens]|Apoptotic chromatin condensation inducer in the nucleus
Gene Name URL
ACIN1
Nucleotide Accession Number
NM_001164814.1NM_001164815.1NM_001164816.1NM_001164817.1NM_014977.3XM_005267418.1

Related Products

CatalogName
OCOA20589-20UGACIN1 Protein Lysate
OCOA20607-20UGACIN1 Protein Lysate
AAP58256-100UGAcin1 Peptide - N-terminal region (AAP58256)
AAP58257-100UGAcin1 Peptide - C-terminal region (AAP58257)
OAMA00822-1MGWAS Antibody
OAMA00821-1MGWAS Antibody
OACD01074-100ULWAS Antibody
OASG07565-100ULWAS Antibody
OACD00878-100ULAT Antibody
OACD06223-1MLON Antibody

Alternative Products

CatalogName
GWB-MV182BAcin1 Antibody

Popular Products