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CAV1 Antibody

CAT: 0247-OAPA00353-5UGSize: 5 µgDry Ice: NoHazardous: No
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CAT#:0247-OAPA00353-5UGSize:5 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
9007-83-4
Gene Aliases
CGL3, PPH3, BSCL3, LCCNS, VIP21, MSTP085
Gene ID
857
Reactivity
Human
Immunogen
The immunogen for anti-CAV1 antibody: anti-human CAV1 mAb, is derived from hybridization of mouse FO myeloma cells with spleen cells from BALB/c mice immunized with recombinant human CAV1 amino acids 1-104 purified from E. coli.
Target
The scaffolding protein encoded by the CAV1 gene is the key component of the caveolae plasma membranes found in most cell types. Cholesterol is vital for caveolae formation and maintenance, and caveolae structure is highly sensitive to cholesterol depletion or treatment with cholesterol binding drugs. CAV1 can tightly and specifically bind free cholesterol and artificial cholesterol containing vesicles. Caveolin 1 links integrin subunits to the tyrosine kinase FYN, which is an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. CAV1 is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase. Caveolin 1 and caveolin 2 are positioned next to each other on chromosome 7 and express co-localizing proteins which form a stable hetero-oligomeric complex cascade. Mutations in the CAV1 gene are linked to Berardinelli-Seip congenital lipodystrophy._x005F
Clonality
Monoclonal
Clone
PAT4C1AT
Type
Monoclonal Antibody
Applications
WB
Purification
CAV1 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Concentration
1 mg/ml
Format
Liquid// PBS, pH-7.4, & 0.1% Sodium Azide Physical Appearance:// Sterile Filtered clear solutionPhysical Appearance:// Sterile Filtered clear solution
Reconstitution
For periods up to 1 month store at 4C, for periods up to 12 months, store at -20C. Prevent freeze thaw cycles. Please prevent freeze/thaw cycles.
Notes
Formerly GWB-BSP887
Fragment
Mouse IgG2b heavy chain and kappa light chain.
NCBI Gene Symbol
CAV1
Host or Source
Mouse
Protein Name
Caveolin-1
Gene Name URL
CAV1

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