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CDKN2A Antibody

CAT: 0247-OALA04824-50UGSize: 50 µgDry Ice: NoHazardous: No
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CAT#:0247-OALA04824-50UGSize:50 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
9007-83-4
Gene Aliases
, INK4A, Multiple tumor suppressor 1, MTS-1, MTS1, p16-INK4A, p16 INK4A, p16INK4A, CDKN2A, cyclin-dependent kinase inhibitor 2A
Accession Number
NP_000068.1
Reactivity
Mouse, Rat, Human
Immunogen
Full length recombinant p16INK4a NP_000068
Target
Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes.
Clonality
Monoclonal
Clone
1E12E10
Conjugation
Unconjugated
Type
Monoclonal Antibody
Applications
ELISA, IHC, IHC-P, WB
Purification
Affinity purified from ascites
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Concentration
1 mg/ml
Format
Liquid// PBS with 0.1% sodium azide and 1% BSA
Buffer
PBS, 0.1% Sodium Azide, 1% BSA
Reconstitution
Short term: store at 4C. Long term: store at -20C. Avoid freeze-thaw cycles.
Fragment
IgG1
Specificity
Targets P16. Shows reactivity with Human, Mouse, and Rat samples.
NCBI Gene Symbol
CDKN2A
Host or Source
Mouse
Gene Name URL
CDKN2A
Nucleotide Accession Number
NM_000077

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