TP53BP1 Antibody

• Gene Name :

  Tumor protein p53 binding protein 1

• Gene Aliases :

  P202, 53BP1, TDRD30, p53BP1

• Gene ID :

  7158

• Accession Number :

  NP_001135451.1

• Reactivity :

  Human, Mouse

• Immunogen :

  Synthetic peptide corresponding to the carboxy-terminus of h53BP1, conjugated to a carrier protein.

• Target :

  This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V (D) J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms.

• Clonality :

  Polyclonal

• Type :

  Polyclonal Antibody

• Applications :

  ICC, IF, IHC, WB

• Purification :

  Purified by antigen-affinity chromatography.

• Assay Protocol :

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Concentration :

  1 mg/ml

• Format :

  Liquid

• Buffer :

  PBS

• Reconstitution :

  Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.

• Fragment :

  IgG

• NCBI Gene Symbol :

  TP53BP1

• Host or Source :

  Rabbit

• Protein Name :

  TP53-binding protein 1; tumor suppressor p53-binding protein 1

• Gene Name URL :

  TP53BP1

• CAS Number :

  9007-83-4

• Nucleotide Accession Number :

  NM_001141979.1