IL10 Antibody

• Gene Name:

  Interleukin 10

• Gene Aliases:

  CSIF, TGIF, GVHDS, IL-10, IL10A

• Gene ID:

  3586

• Accession Number:

  NP_000563.1

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant protein encompassing a sequence within the center region of human IL10. The exact sequence is proprietary.

• Target:

  The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract.

• Clonality:

  Monoclonal

• Clone:

  GT5111

• Type:

  Monoclonal Antibody

• Applications:

  WB, IHC-FFPE

• Purification:

  Affinity purified by Protein G.

• Assay Protocol:

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Concentration:

  1.19 mg/ml

• Homology:

  Cat (86%), Rabbit (83%), Sheep (85%), Rhesus Monkey (93%), Chimpanzee (98%), Bovine (81%), Guinea Pig (88%)

• Format:

  Liquid// PBS

• Reconstitution:

  Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.

• Molecular Weight:

  21 kDa

• Fragment:

  IgG1

• NCBI Gene Symbol:

  IL10

• Host or Source:

  Mouse

• Protein Name:

  Interleukin-10

• Gene Name URL:

  IL10

• CAS Number:

  9007-83-4

• Nucleotide Accession Number:

  NM_000572.2