MAP2K2 Antibody

CAT: 0247-OAGA08492-100ULSize: 100 µLDry Ice: NoHazardous: No
CAT#:0247-OAGA08492-100ULSize:100 µL
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CAS Number
9007-83-4
Gene Name
Mitogen-activated protein kinase kinase 2
Gene Aliases
CFC4, MEK2, MKK2, MAPKK2, PRKMK2
Gene ID
5605
Accession Number
NP_109587.1
Reactivity
Human
Immunogen
Recombinant protein encompassing a sequence within the center region of human MEK2. The exact sequence is proprietary.
Target
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, cognitive disability, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.
Clonality
Monoclonal
Clone
GT1721
Type
Monoclonal Antibody
Applications
WB
Purification
Affinity purified by Protein G.
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Concentration
1 mg/ml
Format
Liquid
Buffer
PBS
Reconstitution
Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
Fragment
IgG1
NCBI Gene Symbol
MAP2K2
Host or Source
Mouse
Protein Name
Dual specificity mitogen-activated protein kinase kinase 2
Gene Name URL
MAP2K2
Nucleotide Accession Number
NM_030662.3

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