MAML2 Antibody

• Gene Name :

  Mastermind like transcriptional coactivator 2

• Gene Aliases :

  MAM2, MAM3, MAM-3, MLL-MAML2

• Gene ID :

  84441

• Accession Number :

  NP_115803.1

• Reactivity :

  Human

• Immunogen :

  Recombinant protein encompassing a sequence within the center region of human MAML2. The exact sequence is proprietary.

• Target :

  The protein encoded by this gene is a member of the Mastermind-like family of proteins. All family members are proline and glutamine-rich, and contain a conserved basic domain that binds the ankyrin repeat domain of the intracellular domain of the Notch receptors (ICN1-4) in their N-terminus, and a transcriptional activation domain in their C-terminus. This protein binds to an extended groove that is formed by the interaction of CBF1, Suppressor of Hairless, LAG-1 (CSL) with ICN, and positively regulates Notch signaling. High levels of expression of this gene have been observed in several B cell-derived lymphomas. Translocations resulting in fusion proteins with both CRTC1 and CRTC3 have been implicated in the development of mucoepidermoid carcinomas, while a translocation event with CXCR4 has been linked with chronic lymphocytic leukemia (CLL) . Copy number variation in the polyglutamine tract has been observed.

• Clonality :

  Polyclonal

• Type :

  Polyclonal Antibody

• Applications :

  IP, WB

• Purification :

  Purified by antigen-affinity chromatography.

• Assay Protocol :

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Concentration :

  1.8 mg/ml

• Format :

  Liquid

• Buffer :

  1XPBS, 20% Glycerol (pH7) . 0.025% ProClin 300 was added as a preservative.

• Reconstitution :

  Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.

• Fragment :

  IgG

• NCBI Gene Symbol :

  MAML2

• Host or Source :

  Rabbit

• Protein Name :

  Mastermind-like protein 2

• Gene Name URL :

  MAML2

• CAS Number :

  9007-83-4

• Nucleotide Accession Number :

  NM_032427.3