STAT3 Antibody

• Gene Name:

  Signal transducer and activator of transcription 3

• Gene Aliases:

  APRF, HIES, ADMIO, ADMIO1

• Gene ID:

  6774

• Accession Number:

  NP_003141.2

• Reactivity:

  Human, Rat, Zebrafish

• Immunogen:

  Recombinant protein encompassing a sequence within the center region of human STAT3. The exact sequence is proprietary.

• Target:

  The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

• Clonality:

  Polyclonal

• Type:

  Polyclonal Antibody

• Applications:

  ICC, IF, WB

• Purification:

  Purified by antigen-affinity chromatography.

• Assay Protocol:

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Concentration:

  1 mg/ml

• Homology:

  Mouse (100%), Rat (99%), Japanese Medaka (85%), Pig (100%), Chicken (98%), Bovine (100%)

• Format:

  Liquid.// 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH 7) . 0.01% Thimerosal was added as a preservative.

• Reconstitution:

  Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4C. For long-term storage, aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.

• Molecular Weight:

  88 kDa

• Fragment:

  IgG

• NCBI Gene Symbol:

  STAT3

• Host or Source:

  Rabbit

• Protein Name:

  Signal transducer and activator of transcription 3

• Gene Name URL:

  STAT3

• CAS Number:

  9007-83-4

• Nucleotide Accession Number:

  NM_003150.3