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KNG1 antibody

CAT: 0247-OAGA00072-100ULSize: 100 µLDry Ice: NoHazardous: No
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CAS Number
9007-83-4
Gene Name
Kininogen-1
Gene Aliases
BK, BDK, KNG, HMWK
Gene ID
3827
Accession Number
NP_000884.1
Reactivity
Human
Immunogen
Recombinant protein encompassing a sequence within the center region of human HMW Kininogen. The exact sequence is proprietary.
Target
High molecular weight kininogen (HMWK) plays an important role in assembly of the plasma kallikrein (see MIM 147910) -kinin system. The KNG1 gene generates both HMWK and low molecular weight kininogen (LMWK) through alternative splicing. Both HMWK and LMWK contain an identical heavy chain consisting of protein domains 1, 2, and 3. However, HMWK contains a 56-kD light chain that consists of domains 5 and 6H, whereas LMWK contains a unique 4-kD light chain that consists of domain 5L. In both proteins, the heavy and light chains are linked by domain 4, which contains the bradykinin (BK) nonapeptide. BK, which is released by plasma kallikrein, is a potent inflammatory mediator that causes vasodilation and enhanced capillary permeability, induces pain, and stimulates production of nitric oxide and prostacyclin (see MIM 601699) from endothelial cells. During vascular damage, BK stimulates smooth muscle proliferation and intimal hypertrophy. Release of BK from HMWK generates a 2-chain HMWK, termed HMWKa, containing the heavy and light chains joined by a disulfide bond.
Clonality
Polyclonal
Type
Polyclonal Antibody
Applications
WB, ICC, IF, IHC-P
Purification
Purified by antigen-affinity chromatography.
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Concentration
1 mg/ml
Format
Liquid.// 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7) with 0.01% Thimerosal was added as a preservative
Reconstitution
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4° C. For long-term storage, aliquot and store at -20° C or below. Avoid multiple freeze-thaw cycles.
Molecular Weight
72 kDa
Fragment
IgG
NCBI Gene Symbol
KNG1
Host or Source
Rabbit
Protein Name
Kininogen-1
Gene Name URL
KNG1

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