CYCS Antibody

• Gene Name :

  Cytochrome c; Cytochrome c, somatic

• Gene Aliases :

  CYC, HCS, THC4

• Gene ID :

  54205; 475258; 100363502; 25309

• Accession Number :

  NP_061820.1NP_001183974.1NP_036971.1

• Reactivity :

  Human, Rat, Rabbit, Dog

• Immunogen :

  Full length recombinant Cytochrome C

• Target :

  Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain._x005F_x000B_Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases._x005F_x000B_Defects in CYCS are the cause of thrombocytopenia type 4 (THC4) also known as autosomal dominant thrombocytopenia type 4. Thrombocytopenia is the presence of relatively few platelets in blood. THC4 is a non-syndromic form of thrombocytopenia. Clinical manifestations of thrombocytopenia are absent or mild. THC4 may be caused by dysregulated platelet formation.

• Clonality :

  Polyclonal

• Type :

  Polyclonal Antibody

• Applications :

  WB

• Purification :

  Ammonium Sulfate Precipitation

• Assay Protocol :

  Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol

• Concentration :

  1 mg/ml

• Format :

  Liquid.// PBS with 0.08% sodium azide

• Reconstitution :

  Product should be stored at -20C. Aliquot to avoid freeze/thaw cycles

• Molecular Weight :

  14 kDa

• Fragment :

  IgG

• NCBI Gene Symbol :

  CYCS, CYCS, CYCS

• Host or Source :

  Sheep

• Gene Name URL :

  CYCSCYCSCycs

• CAS Number :

  9007-83-4

• Nucleotide Accession Number :

  NM_018947.5NM_001197045.1NM_012839.2