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CYCS Antibody

CAT: 0247-OAEG00823-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0247-OAEG00823-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
9007-83-4
Gene Name
Cytochrome c; Cytochrome c, somatic
Gene Aliases
CYC, HCS, THC4
Gene ID
54205; 475258; 100363502; 25309
Accession Number
NP_061820.1NP_001183974.1NP_036971.1
Reactivity
Human, Rat, Rabbit, Dog
Immunogen
Full length recombinant Cytochrome C
Target
Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain._x005F_x000B_Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases._x005F_x000B_Defects in CYCS are the cause of thrombocytopenia type 4 (THC4) also known as autosomal dominant thrombocytopenia type 4. Thrombocytopenia is the presence of relatively few platelets in blood. THC4 is a non-syndromic form of thrombocytopenia. Clinical manifestations of thrombocytopenia are absent or mild. THC4 may be caused by dysregulated platelet formation.
Clonality
Polyclonal
Type
Polyclonal Antibody
Applications
WB
Purification
Ammonium Sulfate Precipitation
Assay Protocol
Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Reconstitution & Storage Instructions Reconstitution & Storage Instructions Western Blotting/Immunoblotting (WB/IB) Protocol Western Blotting/Immunoblotting (WB/IB) Protocol Immunohistochemistry (IHC) Protocol Immunohistochemistry (IHC) Protocol Immunocytochemistry (ICC) Protocol Immunocytochemistry (ICC) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol Blocking Peptide Competition Protocol (BPCP) Blocking Peptide Competition Protocol (BPCP) Immunoprecipitation (IP) Protocol Immunoprecipitation (IP) Protocol Antibody Array (AA) Protocol Antibody Array (AA) Protocol
Concentration
1 mg/ml
Format
Liquid.// PBS with 0.08% sodium azide
Reconstitution
Product should be stored at -20C. Aliquot to avoid freeze/thaw cycles
Molecular Weight
14 kDa
Fragment
IgG
NCBI Gene Symbol
CYCS, CYCS, CYCS
Host or Source
Sheep
Gene Name URL
CYCSCYCSCycs
Nucleotide Accession Number
NM_018947.5NM_001197045.1NM_012839.2

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