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Isocucurbitacin B

CAT: 0804-HY-N4189-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N4189-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Isocucurbitacin B is a natural terpenoid compound found in Pedicellus Melo. Isocucurbitacin B can inhibit the PI3K/AKT, MAPK, and STAT3 signaling pathways and downregulate CAV1 expression. Isocucurbitacin B can inhbit cancer cell proliferation, migration and invision. Isocucurbitacin B can induce apoptosis and cause G2/M phase arrest. Isocucurbitacin B can decrease intracellular cholesterol and PH levels and increase intracellular calcium levels.  Isocucurbitacin B can be used for the research of cancer, such as glioma[1][2].
CAS Number
[17278-28-3]
UNSPSC
12352211
Target
Akt; Apoptosis; p38 MAPK; PI3K; STAT
Type
Natural Products
Related Pathways
Apoptosis; JAK/STAT Signaling; MAPK/ERK Pathway; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/isocucurbitacin-b.html
Purity
98.98
Solubility
10 mM in DMSO
Smiles
C[C@]12[C@@]([C@]([C@@](C)(O)C(/C=C/C(C)(C)OC(C)=O)=O)([H])[C@H](O)C1)(CC([C@]3(C)[C@@]2([H])CC=C4[C@@]3([H])CC([C@@H](O)C4(C)C)=O)=O)C
Molecular Formula
C32H46O8
Molecular Weight
558.70
References & Citations
[1]Han M, et al. Isocucurbitacin B inhibits glioma growth through PI3K/AKT pathways and increases glioma sensitivity to TMZ by inhibiting hsa-mir-1286a. Cancer Drug Resist. 2024;7:16. Published 2024 May 8.|[2]Han M, et al. Isocucurbitacin B inhibits gliomas through the promotion of anoikis by targeting caveolin 1. Cancer Lett. 2025;629:217873.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
STAT3

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